Grand Rounds Recap 02.10.2021


Ultrasound Grand Rounds: Respiratory Distress WITH Dr. Duncan

Point of Care Ultrasound in M&M Cases in EM: Who Benefits the Most?

  • In cases where POCUS was not used, retrospective review determined it could have prevented 45% of M&M cases

  • Cardiac and lung ultrasounds were thought to have the most potential

  • 1% of total cases (9% of cases selected for presentation) where POCUS possibly had adversely affected the outcome

  • Respiratory Distress in Ultrasound, cases and pearls

    • 60 year old female with shortness of breath. HR 110, BP 240/110, RR 40, SpO2 90% on 15L NRB

      • POCUS shows B-lines, you have concern for flash pulmonary edema and start patient on nitro and bipap.

      • B-lines replace A-lines, extend throughout the edge of the screen, represents an interstitial process

      • Focus position (setting on US machine): for this POCUS application place it at the parietal surface for image optimization

      • Angle of Insonation: you MUST see either A lines or B lines in lung ultrasound, if you don’t then you need to change the angle

    • 55 year old male with shortness of breath. HR 110, BP 180/110, RR 40, SpO2 85% on NRB

      • A-lines generally mean normal lung (though sometimes pneumothorax can have A lines)

      • A-lines are equidistant from each other

      • Curvilinear/phased array probe

        • Lower frequency, deeper structures beyond pleural line

        • Better for B lines, pleural effusion, PNA

      • Linear

        • Higher frequency, best for artifacts at pleural line

          • Lung sliding, PTX, subpleural consolidations

    • 63 year old female with shortness of breath. HR 90, BP 180/110, RR 30, SpO2 95% on 4L NC

      • POCUS echo shows severely depressed LVEF and pleural effusion

      • POCUS lung shows large anechoic pleural effusion

      • Concern for CHF

    • Literature: Diagnosing Acute Heart Failure in the ED: A systematic review and meta-analysis

      • Lung US +7.4 LR

      • Reduced EF +4.1 LR

      • CXR +4.8 LR

      • BNP +0.11, +0.29

    • Lit: Diagnostic Accuracy of POC Lung US and Chest Radiography in Adults with Symptoms Suggestive of Acute Decompensated Heart Failure: A systematic Review and Metaanalysis

      • Lung US is more sensitive and specific than CXR

    • 70 year old male with SOB. Hx of lung cancer on chemo. HR 115, BP 90/50, RR 30, SpO2 95% on 4L NC

      • POCUS shows large pericardial effusion

      • Rapid effusion is more problematic than slow effusion over time

      • Signs of tamponade: valves closed RA collapse, plethoric IVC <50% collapse, valves open and RV collapse, MV inflow variation >25%

    • Lit: Emergency department POC ultrasound improves time to pericardiocentesis for clinically significant effusions

      • Time to pericardiocentesis

        • POCUS 11.3 hrs

        • Non-POCUS 70.2 hours

    • 85 year old male with hx of CHF and CAD. 

      • Lung US shows B lines

      • Right lung base shows a consolidated lung and small pleural effusion

      • How to differential PNA vs atelectasis?

        • Dynamic air bronchograms - highly sensitive for PNA

        • Shred sign - irregular pleural surface

    • Lit: Accuracy of Lung US versus Chest radiography for diagnosis of adult community aquired PNA: Review of Lit and meta-analysis

      • Lung US sensitivity 95%

      • CXR sensitivity in the 70s%

      • Also better sensitivity in pediatric settings when reviewing pediatric literature

    • 40 year old male in MVC. Has SOB. HR 115, BP 90/50, RR 30, 95% on 4L NC

      • You include lung in your E-FAST

        • No lung sliding on the left, concern for pneumothorax

        • Bar code sign on M-mode

        • Lung point

        • Lung pulse sign: contraction of heart moving the lung tissue, can see small pulsations along the pleural line. Not consistent with a pneumothorax

        • False positive pneumothorax: beware in certain conditions such as COPD or poor ventilation, will see less lung sliding

    • Lit: Accuracy of US in dx of PTX: Comparison between neonates and adults

      • Absence of lung slide: sens 87, spec 99.4

      • Lung point sens 82, spec 100

      • Accuracy of CXR? A different study showed pooled sens ~30-50%

    • 56 year old F with hx of ovarian cancer on chemo/radiation. HR 115, BP 80/50, RR 36, 95% on 2L NC

      • POCUS shows left ventricle D sign

      • Signs of right heart strain, concern for pulmonary embolism

        • Paradoxical septal motion

        • Enlarged RV

        • D-sign

      • False D-sign can occur if you have poorly optimized image

    • 35 yo F with shortness of breath. Hypoxic and in respiratory distress

      • POCUS shows B-lines

      • Note some irregularity to pleural lines

      • Covid 19 and Lung US

        • Subpleural consolidations

        • Multifocal B lines

        • Literature shows Lung US sensitivity 97.6%, CXR 69.9%

    • Lit: POCUS for Evaluation of Acute Dyspnea in the ED

      • Time to US diagnosis: 24 min +/- 10 min

      • Time to standard diagnosis: 186 min +/- 72 min

  • How to clinically integrate?

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R4 Case Followup WITH Dr. Iparraguirre

Elderly female who fell and developed a headache. She took aspirin at home which helped with her symptoms. She then developed slurred speech and that her hands were weak/clumsy. Vitals were normal. Exam was normal except for a slight limping gait (she stated she felt off balance).

  • The physician-patient relationship

    • Four models

      • Paternalistic: give patient treatments based on our point of view. Lean towards their wellbeing rather than their autonomy

      • Informative: we provide all the data, but we allow the patient to guide their management

      • Interpretative: we provide data, but we take patient’s beliefs and values into consideration and help them interpret to better guide their care

      • Deliberative: Similar to interpretative, but we help the patient make the best decisions for their care

    • What constitutes a good doctor? (From patient’s point of view)

      • A study out of Mayo found that patients valued:

        • Empathy, humane, personal, forthright, confident, respectful, thorough

    • How do we move Beyond Empathy?

      • Engagement, competency, imagination, care, active listening

  • Patient had metastatic cancer on head CT

  • SPIKES

    • Delivering bad news to the patient

    • Setting Up (S)

    • Perception (P)

    • Invitation (I)

    • Knowledge (K)

    • Emotions/Empathy (E)

    • Strategy and Summary (S)

  • Takeaways

    • Clear your head

    • Our patients are human too

    • Educate, inform, and guide

    • Go beyond empathy

    • Bad news, good doctor

    • Treat our patient

    • You have more impact than you think


R1 Clinical Knowledge: VP Shunts WITH Dr. Klestel

 CSF made by choroid plexus

  • Mainly in lateral ventricles

  • Flows into 3rd ventricle by foramen of monro

  • Into the 4th by aqueduct of sylvius

  • Enters subarachnoid space and bathes spinal cord and brain

  • Reabsorbed by arachnoid villi

  • About 500cc/ day is made

  • Hydrocephalus is excess quantity of CSF

    • Communicating

      • Decreased absorption

        • Defect with arachnoid villi

        • Inflammation

        • Fibrosis

      • Increased production

    • Noncommunicating

      • Obstruction of CSF flow

        • Congenital such as Arnold-Chiari

        • Acquired such as a tumor

    • Subtypes:

      • Normal pressure hydrocephalus

        • Urinary incontinence, dementia, ataxic

        • No signs of increased ICP

      • Hydrocephalus ex vacuo

        • Not true hydrocephalus

        • Ventricles appear to be enlarged due to atrophy

        • ICP and CSF flow is normal

    • Monro-Kellie Doctrine

      • Skull is a fixed, rigid space

      • Must accommodate CSF, blood, brain

      • Increase in one component without compensatory reduction in another will lead to increased ICP

    • Hydrocephalus clinical signs

      • Morning headache

      • Vomiting

      • Papilledema

      • Focal neuro deficits

        • Abducens nerve palsy

      • Cushings phenomena

      • Herniation

        • Decreased consciousness

        • Oculomotor nerve palsy

        • Posturing

      • Infants have fontanel

        • Look for bulging of fontanel

        • Increase head circumference

        • Separation of cranial sutures

    • Definitive treatment: cerebral shunt placement

      • Indwelling catheter

        • Moves excess CSF to systemic circulation

      • Typically in lateral ventricle

      • Distal tip can vary in location, mostly VP

      • CSF flow is controlled by one way valve

        • Differential pressure valve: When CSF goes above set pressure, it will be drained

        • Can also set a physiologic pressure valve

      • Distal tubing travels within subcutaneous tissue

      • Distal catheter tip enters peritoneal cavity

        • Left free floating

    • Complications

      • Commonly occur shortly after placement

      • Pediatric patients:

        • Signs of failure for peds patients within 5 months of placement

          • Decreased LOC PPV 100%

          • Bulging fontanel PPV 92%

          • Nausea and vomiting PPV 79%

          • Irritability PPV 78%

        • If between 9 months to 2 years

          • Decreased LOC PPV 100%

          • Loss of milestones PPV 83%

      • Verbal patients have signs of increased ICP

        • Morning headaches

        • Ataxia hyperrfelexia, spastic

        • Nausea and vomiting

        • Reduced responsiveness, cushings

    • Undershunting

      • Shunt obstruction: may occur at proximal ventricular catheter, the valve, or the distal catheter

        • Vast majority occur due to proximal obstruction

        • Distal obstructions are less common, about 14%

      • Mechanical failure

        • misplacement/ migration/ disconnection

      • Shunt series XR and head CT can be used for evaluation

        • These patients get a lot of radiation throughout their life

    • Infection

      • Second most common cause of shunt failure: incidence of 8-10%

      • Tend to occur within first 6 months

        • Due to contamination from intraop due to skin flora 

        • Staph epidermidis, staph aureus, pseudomonas, gram negative rods

      • Need to tap the shunt

        • Usually performed by neurosurgery

        • Done sterilely and needle may damage the system

      • CSF labs evaluated the same as you would from an LP

      • Adults: vancomycin and cefepime (to cover pseudomonas)

      • Children: vanc and cetriaxone

    • Overshunting

      • Shunt draining too much CSF, leads to extra axial fluid collections

      • Need adjustments to their valve

      • Slit ventricles can occur in children

    • EM approach

      • Unstable?

        • Intubate, mannitol/hypertonic, HOB >30, consult NSGY

      • Infection?

        • NSGY to tap shunt

        • Empiric antibiotics


Visiting Professors Lecture WITH Drs. Koyfman and Long

Cerebral Venous Thrombosis

  • Most commonly at superior sagittal sinus and transverse (lateral) sinus

  • Oftentimes patients have multiple areas involved

  • 85% have underlying risk factor for thrombosis

  • Headache is most common presentation

    • Chronic, gradually worsening, worsens with valsava

    • Focal neurologic abnormality

      • Vision change, motor weakness

    • Seizures (generalized or partial)

    • Encephalitis with AMS

  • Scenarios warranting investigation

    • Headache in patient with risk factors and focal neuro findings

    • Stroke without typical risk factors or in setting of seizure

    • Unexplained intracranial hypertension

    • Multiple hemorrhagic infarcts, or if it does not fit a arterial vascular distribution

  • ‘Dense triangle sign’ on non con CT can be seen, do not depend on this

  • CT venogram >95% sens and spec

  • MR venogram is best test

  • Treat elevated ICP, antiepileptics if seizing, anticoagulation

  • Ludwigs Angina

    • Infection of submandibular face that can lead to airway occlusion

    • Odontogenic (mandibular molars), piercings, diabetes, immunocompromising disorders

    • Beware of tripod positioning, trouble with secretions, cannot lie flat, protruding tongue and lower chin

    • This is a clinical diagnosis, CT may be helpful but patient may have trouble laying flat and compromise airway

    • Airway

      • Awake intubation

        • Topicalize, ketamine, prep for cric

        • Supraglottic airway likely will not work

  • Cauda Equina syndrome

    • Often have a delay in diagnosis (11 days from symptom onset)

    • CES stages

      • Suspected

      • Incomplete

      • Retention

      • Complete

    • History: don’t forget about on bladder, bowel, sexual dysfunction

    • Physical: motor, sensation, postvoid residual

      • Post void residual volume

        • If patient has <100 cc, probably not advanced cauda equina

    • MRI is diagnostic modality of choice

    • Treatment: surgery

      • Urinary problems at presentation = poor outcome

  • Acute Cholangitis

    • Bacterial infection of the biliary tract as a result of obstruction

    • Common bile duct obstruction

      • Extrinsic (stricture or mass)

      • Gallstone

    • Mortality reaches 100% if obstruction is not decompressed

    • Charcots Triad and Reynold’s Pentad

      • Charcot <25% of patients

      • Reynolds even more rare

    • WBC, GGT, Alkaline phosphatase, LFT, blood cultures

    • Tokyo Guidelines for Acute Cholangitis, on MDCalc

    • Source control, fluid resuscitation, broad antibiotics

  • Fournier’s Gangrene

    • Risk factors include diabetes, immunocompromised, alcohol use disorder, hygiene, trauma to area

    • Sources: GI and GU track, cutaneous injuries

    • Most are polymicrobial

    • Clinical diagnosis

      • Don’t rely on fever, bullae, crepitus

    • POOP: pain out of proportion

    • LRINEC Score

      • Cannot be used to rule out disease, generally a poor tool

    • POCUS and CT can be helpful

    • Treatment: surgery, resuscitation, broad antibiotics, glycemic control    


R2 QI/KT: Hypothyroid and Myxedema Coma WITH Drs. Gressick and Meigh

Myxedema coma

  • Severe life threatening manifestations of hypothyroidism

    • It is a critical physiologic state

    • Name from the non-pitting edema seen in this condition

    • Patient does not need to have a coma, often just AMS

  • Epidemiology

    • 0.22/million/year

    • 80% female

    • Peak incidence in 7th decade of life

    • 90% in winter months, less common in tropical areas

    • Mortality is 30-60%

  • Factors associated with morality

    • State of consciousness on admission

    • APACHE II Score

    • Bradycardia, hypotension, need for mechanical ventilation, hypothermia, sepsis, lower GCS, higher SOFA score

    • T4 and TSH was not statistically significant

  • Systemic Effects

    • Nervous system

      • AMS/confusion

        • Likely multifactorial

      • Seizure (hypoglycemia or hyponatremia)

      • Delayed relaxation of DTR (Woltman Sign)

    • Cardiovascular

      • Decreased ionotropy and chronotropy

      • Prolongs cardiac action potential → risk for torsades

      • Peripheral vasoconstriction

        • Diastolic HTN

      • Decreased cardiac output

    • Respiratory

      • Hypoventilation

    • Renal

      • Hyponatremia

        • Impaired free water excretion

        • Impaired sodium reabsorption

    • Other

      • Decreased vWF → coagulopathy

      • Pleural and pericardial effusions from increased vascular permeability

      • Decreased GI motility

  • Inciting Events

    • Hypothermia

    • Infections and sepsis

    • CVA

    • CHF

    • GI bleed

    • Raw bok choy

    • Trauma

    • Drugs (anesthetics, sedatives, tranquilizers, narcotics, amiodarone, lithium)

    • Withdrawal of thyroid supplements

  • Presentation

    • This is a clinical diagnosis

    • Physical exam findings:

      • Facial edema, skin changes, peripheral edema, past surgical scars on neck, laryngeal edema, tongue edema, AMS

    • Vitals

      • Hypothermia in 90% of patients

      • Respiratory depression/hypoxemia

      • Diastolic hypertension → hypotension

      • Bradycardia

    • TSH may be high, low or normal

    • T4 usually low

    • Send cortisol level in altered hypothermic patients

  • Treatment

    • Thyroid hormone replacement

    • T4 vs T3 treatment

      • Studies recommend T4 monotherapy

      • UC does not carry IV T3

    • T4 dosing

      • PO T4 has multiple factors that affect bioavailability

      • IV T4 is recommended

        • 200-400 micrograms IV T4

      • No RCTs, mostly case series, very little has changed in the past half decade

    • Glucocorticoids

      • Empiric hydrocortisone 100mg IV q8hr is recommended by some groups since hypopituitarism and hypoadrenalism can mimic myxedema coma and can also occur simultaneously

    • Airway Management considerations

      • Watch for edema in the mouth, such as the tongue

      • Can have lung pathologies such as edema and effusions

      • Neuromuscular weakness

    • Hypotension

      • IV fluids

      • Consider POCUS echo

      • Pressors

    • Hypothermia

      • Slow more gentle approach with passive rewarming

    • Treat hypoglycemia

    • Manage inciting factors

    • Consider blood cultures and antibiotics

    • Correct electrolyte abnormalities

    • Consider DDAVP for bleeding issues

    • Do not await for thyroid studies to begin treatment


MIS-C and Kawasaki WITH Dr. Krack

Three phenotypes of children with MIS-C

  • Group with shock with evidence of myocardial injury

  • Group that met AHA criteria for KD

  • Group with fever and inflammation that did not have shock or did not meet clinical criteria for KD

  • Kawasaki Disease: Epidemiology

    • Cause is unknown

    • Estimated incidence in North America ~25 cases  per 100k in children <5 years of age per year

      • Japanese incidence ~10x higher

    • Ratio males to females is 1.5:1

    • KD affects predominately young children

    • More common in winter and early spring in North America

  • Pathology

    • Affects muscular arteries

      • Coronary often affected, but can affect other areas too

    • Systemic inflammation in all medium sized arteries and in multiple organs during acute febrile disease

  • Diagnosis

    • Classic KD

      • 5 or more days of fever (typically high spiking and remittent)

      • AND 4 or more of the 5 principal clinical features

      • Can also be 4 days of fever and 5/5 clinical features

    • Atypical KD

      • Fever 5 or more days

      • AND 2-3 clinical criteria and classic lab changes

      • Infants less than 6 months are unique: with unexplained fever for 7 or more days

  • KD treatment

    • IVIG 2g/kg given as a single IV infusion

      • Reduces absolute risk of coronary artery lesions from 25% to 4%

      • Treatment is relatively benign, delayed treatment is not

  • CDC case definition for MIS-C

    • <21 years presenting with fever, lab evidence of inflammation, and evidence of severe illness requiring hospitalization with greater than 2 organ system involvement

    • Covid exposure

    • No other plausible diagnosis

  • MIS-C features

    • Mean age 8-10 years

    • Seen more in children of African, Caribbean, and Hispanic Descent

    • Clinical: abdominal pain, diarrhea, vomiting, multi-organ involvement

    • Cardiac features

      • About half show moderate to very severe myocardial involvement, much greater than KD

    • Younger kids have more KD-like features

    • Older kids have more GI symptoms, cardiac features, shock

  • MIS-C Treatment

    • IVIG

    • Constantly changing recommendations