Grand Rounds Recap 5.3.23
/APRIL Morbidity & Mortality Report - R4 Capstone: CASES OF Near misses - R1 clinical knowledge: TBI’s - air care ground rounds
MORBIDITY AND MORTALITY REPORT WITH DR. BROADSTOCK
Suicidal Ideation & Behavior with Concomitant Substance-Use
Difficult to distinguish suicidal ideation/behavior from primary decompensated psychiatric disease versus substance-induced in the ED
Statement of Belief
Aka pink slip, 72 hour hold, involuntary civil commitment, etc.
Allows for the patient to be held for a psychiatric evaluation
Varies greatly based on state laws
In OH, this means patient can be held for 24h prior to being evaluation by a psychiatrist & may be held for additional 72h after that initial evaluation is performed
In OH, can be signed by physician, psychologist, mental health NP, mental health clinical nurse specialist, health officer, parole officer, police officer or sheriff
In other states, such as CA and WA, physicians can not sign a psychiatric hold
Criteria for an Ohio Statement of Belief
Risk of physical harm to self
Evidenced by threats of, or attempts at, suicide or self harm
Risk of physical harm to others
Evidenced by threats of, or recent homicidal or violent behavior, geared towards others
Person is unable to provide for one’s basic physical needs because of underlying mental illness
Would benefit from treatment in a hospital for mental illness and is in need of such treatment as manifested by evidence of behavior that creates a grave and imminent risk to substantial rights of others or himself
Typical hospital resources deployed with a statement of belief
Sitter at bedside
Physical restraints
Need to be conscious of the restraints ordered
nonviolent restraints require provider orders every 24 hours and nursing reassessment every 2 hours
violent restraints require provider order every 4 hours, and nursing reassessment every 15 minutes with documentation every hour
Suicide precautions
Statement of belief is different from a medical hold
Useful in preventing departure and preserving health while making attempts to determine capacity and contact the appropriate decision makers
This is most appropriate for patients without capacity intending to leave prior to completion of medical care
Not appropriate for patients who need constant supervision
Acute Angle Closure Glaucoma
2nd most common cause of vision loss worldwide
Risk factors
FHx
Age >60yo
Female
Far-sightedness
Certain medications (including HCTZ, albuterol, SSRI, TMP-SMX)
Inuit or Asian ethnicity
Pathophysiology
Ciliary body makes the aqueous humor
Absorbed by the trabecular meshwork (between iris and cornea)
Acute Angle Closure Glaucoma occurs when the angle between the iris and cornea becomes narrowed
Presentation (cause of painful vision loss)
Symptoms
Decreased vision
Halos around eyes
Usually starts in dim light
Headache
Rare cause of headaches
Eye pain
Nausea, vomiting
Physical exam
Conjunctival injection
Poorly reactive pupil
Mid-dilated pupil
Elevated IOP
Shallow anterior chamber
Diagnosis
Unfortunately, high rate of misdiagnosis
Low threshold to measure IOP whenever there is a concern
Treatment
PASTA mnemonic
Pilocarpine 2%, 1 drop
Cholinergic agent causes pupil constriction
This opens the trabecular meshwork & promotes aqueous humor drainage
Apraclonidine 1%, 1 drop (or brimonidine)
Alpha-2 agonist
Reduces aqueous humor production
Sit-up
Reduces IOP by 2-4mmHg
Timolol 0.5%, 1 drop (or cosopt- which is a combination of timolol and dorzolamide [a carbonic anhydrase inhibitor])
Beta-blocker
Reduces aqueous humor production
Acetazolamide, 500mg PO or IV
Carbonic anhydrase inhibitor
Reduces aqueous humor production
Monitor IOP closely
Recheck q30mins
Redose medications every 30-60mins if no improvement
Fall with Multiple Injuries
70% of sentinel medical errors occur due to miscommunication
50% of those occur during the signout process
Common errors stem from errors and/or emission of important physical exam findings, test results, imaging studies, etc.
Typically leads to increase LOS in the ED
Can potentially be mitigated with oncoming provider typing notes or reviewing the EMR during actual signout process
Additionally, can implement a checklist to ensure all HPI, exam findings, testing results, etc are addressed during signout process
Be mindful of common pitfalls during the signout process:
Movement of patient to a different location in the ED
Imaging/labs that result near or at the time of signout
Lack of access to computer to view results in real-time during the signout
Distractions & interruptions that occur during signout
Atypical ACS
Not all patients with ACS present with typical chest pain, making the diagnosis rather difficult in the ED
43% of patients with a NSTEMI, as well as 27% of those with a STEMI, will present without chest pain
In these patients presented without chest pain, ACS was not properly diagnosed in about 23% of patients
This leads to an increase in mortality, as well as decrease typical ACS treatments, in these patients presenting with atypical chest pain
STEMI patients presenting without typical chest pain had higher in-hospital mortality compared to those presenting with chest pain (OR 1.38)
NSTEMI patient presenting without typical chest pain had higher in-hospital mortality compared to those presenting with chest pain (OR 1.31)
Additionally, those with atypical chest pain who are ultimately diagnosed with ACS are less likely to receive PCI, tPA, ASA within 24h, BB at discharge, etc.
Highlights the importance of diagnostic momentum in the ED
Risk factors for atypical presentation of ACS include
Female sex
Older age
Underlying DM
Pre-existing heart failure
This case was especially difficult because of a concurrent bundle branch block
Makes EKG interpretation of a STEMI even more difficult
This case also highlights the importance of involving palliative care team when possible
Patient had a poor understanding of proposed procedures, which led to initial refusal of care in the ICU
Palliative care team was essential in discussing procedures and treatment plan with patient in CVICU
Penetrating Lower Extremity Injury
Traumatic penetrating vascular injuries carry high rates of morbidity & mortality
Such as formation of DVT’s & infections, as well as need for fasciotomy, & amputation
EAST trauma guidelines
Level I recommendation
CTA is the test of choice for detection of vascular injury from a penetrating injury
Nearly 100% sensitive
Level II recommendation:
If hard-signs of an arterial injury are present, need OR exploration
Hard signs: pulse deficit, pulsatile bleeding, bruit, thrill, and/or expanding hematoma
If no hard signs, yet abnormal physical exam and/or ABI<0.9, then need further evaluation
Usually with CTA imaging
If normal physical exam & ABI>0.9, may be discharged
Important to note that when used in isolation, ABI’s have a poor sensitivity for detecting vascular injuries
Nonetheless, normal ABI’s WITHOUT associated hard or soft signs, has a high negative LR for a vascular injury
Yet soft signs include delayed cap refill, venous oozing, hematoma, reduced distal pulses (which are all commonly seen with penetrating injuries)
As well as history of hemorrhage/hypotension, bruit, fracture, major tissue defect
Most clinical decision making and practice variation involves patients with no hard signs, normal ABI’s, yet presence of one or more soft signs
Tintinalli’s advocates for CTA’s in all these patients
Yet close observation in the ED with plan to repeat ABI’s can be considered as well
Calcium Channel Blocker Overdose
Calcium channel blocker overdoses involves high morbidity and mortality, therefore typically require aggressive resuscitation
Management of CCB OD
GI decontamination with charcoal
1g/kg
If patient arrive 1-2 hours after ingestion
Patient needs to be awake, alert and able to participate in ingestion of activated charcoal
Especially important for medications with a long half-life (such as amlodipine)
High-dose Insulin Therapy
1u/kg IV bolus, followed by 1-10u/kg/hr infusion
Remember to replete K+ and glucose as needed
Insulin secretion is reduced by calcium channel blockade in pancreatic cells
Leads to a hypo-insulin state and therefore poor glucose utilization in CCB OD
Ultimately leading to myocardial dysfunction
High-insulin allows increase in inotropy by supply cardiomyocytes with much-needed glucose
Calcium
1-5g IV Calcium Chloride
CCB OD involves a calcium-deprived state
Therefore, excess serum calcium will outcompete for the L-type calcium channels
Lipid Emulsion
20% lipid emulsion 1.5cc/kg, followed by 0.25-0.5cc/kg/mib infusion for 30-60mins
Intralipid acts as a lipid sink that pulls drug molecules into the plasma
Additionally, intralipid serves as an energy substrate for cardiomyocytes
PLEX Therapy
Allows elimination of the CCB because they are protein-bound
Of note, no role for iHD as most of these drugs bind to serum proteins
Nitric Oxide Scavengers
Typically considered for refractory vasoplegia as an adjunct therapy
Methylene Blue
1mg/kg over 5-30mins
Inhibit NO synthase, therefore preventing peripheral vasodilation
Drawbacks
Serotonergic
Caution in those with G6PD deficiency
Unsafe in pregnancy
Falsely low SpO2
Hydroxocobalamin
5g over 15 minutes
Inhibits NO activity, therefore preventing peripheral vasodilation
Drawbacks
Expensive
Causes hypertension
Red urine up to 6 weeks
Lab anomalies (hgb, basophils, glucose, bili, alk phos, coags are all affected)
Pneumoperitoneum due to a Penetrating Duodenal Ulcer
Patient presented with hypotension and preceded to suffer a cardiac arrest
ROSC after 2 rounds of ACLS
Started on empiric antibiotics
Subsequent CT scans in revealed pneumoperitoneum
Seen in real-time while patient was still in the CT scanner
Consulted ACS emergently
Underwent emergent ex-lap
Found to have a perforated duodenal ulcer
Successful, aggressive resuscitation, as well as reviewing images in real-time & getting consultants involved early led to this patient’s successful outcome
Discharged to inpatient rehab on HD23
Presented as the win for the month
R4 CASE FOLLOW-UP: CASES OF NEAR MISSES WITH DR. MULLEN
Case #1
Young male presenting with a left eye injury with concerns of wood particles in his eye
On exam, reduced visual acuity and small amount of fluorescein uptake noted
Initial concern for corneal FB
First attempt for removal with a cotton swab
Then called ophthalmology, who had concern for corneal laceration & subtle positive Seidel's sign
Subsequent CT scan showed an unexpected nail embedded in the affected eye
Found to have an ocular foreign body with globe rupture
Went to OR for extraction and corneal laceration repair
Risk factors for corneal FB:
Males in their 30’s
Usually occurs at work or home
Usually involves sharp objects such as nails, scissors, screwdrivers
Severity of injury depends on:
Size, shape of object
Speed at which it hits the eye
Organic material are at most risk of inflammation/infection such as wood
Evaluation
Try to AVOID excess pressure on the eye
CT is the imaging modality of choice
Can consider US while consciously applying minimal pressure on the eye
avoid MRI if unsure of composition
Surgical management
Ophthalmology consult early on, as these patients will likely need surgical manipulation
Medical management
Antibiotics, eye shield, tetanus vaccine
Prognosis
Poor visual prognosis if metal-on-metal mechanism, initial visual acuity is poor, presence of afferent pupillary defect, increase wound size, younger patient, presence of hyphema/vitreous hemorrhage, endophthalmitis
Case #2
Middle-aged female presenting with atraumatic R eye redness and pain
Also reported nausea, vomiting, dizzy, fatigued
As well as LLQ abdominal pain
Physical exam
Normal ocular exam
Yet, notable LLQ abdominal pain
Testing
Unremarkable CBC, BMP, LFT’s, hsTN, UA
NSR on EKG
Unexpectedly found to have a positive b-HCG & then a serum b-HCG quantitative level of >79,000
Found to have an IUP on bedside US
Patient did not know she was pregnant at the time
This was a non-IVF assisted pregnancy
Woman’s peak reproductive years between teens to late 20’s, yet can still get naturally pregnant at an older age as well
By age 30, fertility begins to decline
By age 45, unlikely to get pregnant naturally
Radiology department typically uses age of 60yo as cut-off for bHCG prior to CT scans
Case #3
Female in her 30’s with a PMH of seizures presenting with AMS
Collateral from parent reveals that the patient typically develops agitation/combativeness after a seizure
Also, concerns for poor adherence to prescribed AED regimen (which consists of Depakote)
Chart review with multiple ED visits with agitation in the postictal state
Physical exam
Mumbled speech, head nodding, not following commands, RUE weakness
Meanwhile, also found to be agitated and intermittently yelling at staff
Labs were overall reassuring
Normal CBC, BMP, coingestant levels, ethanol levels, etc.
CT without contrast notable for L MCA ischemic stroke
Subsequently underwent thrombectomy
Left M2 occlusion was evacuated (TICI 2b re-perfusion)
Prolonged NSICU admission
Found to have a protein C deficiency and a small PFO
Follow-up since discharge
Issues with emotional lability
Yet, 5/5 strength in all extremities
Also, able to ambulate on her own without documented ataxia
Though rare, young patients can still develop strokes
Multiple risk factors specific to women include: pregnancy, contraception use with estrogen
Cardiovascular risk factors include: HTN, AF, DM, obesity
Lifestyle risk factors include: tobacco-use, poor diet, heavy EtOH use, drug use
Other risk factors include: PFO, inherited thrombophilias or prothrombotic/hypercoagulable states
R1 CLINICAL KNOWLEDGE: TRAUMATIC BRAIN INJURIES WITH DR. HAJDU
Mild TBI’s & Concussions in the Emergency Department
TBI’s are relatively common
>3 million TBI’s in the US annually
2.5 million presentation to ED’s throughout the US
Usually occur due to falls
Also commonly occur due to sports, MVC’s, etc.
18-24yo make up majority of ED presentation
Meanwhile, >75yo make up majority of patients with mortality and morbidity due to TBI’s
Definition of a TBI
Traumatically induced, physical disruption of the brain that includes period of LOC, loss of memory for that event, or any alteration in mental state at the time of following the event
Classification based on GCS
Mild (GCS 13-15)
further broken down to uncomplicated versus complicated
complicated mild TBI involves an acute intracranial abnormality on neuroimaging
Moderate (GCS 9-12)
Severe (GCS 3-8)
Definition of a Concussion
Multiple definitions
Commonly used synonymously with an uncomplicated mild TBI
Yet can also be used to describe the symptoms that patient may experience following a mild TBI
Entirely a clinical diagnosis with four main symptom domains
Emotional functioning
emotionality out of proportion to circumstances
Impaired cognitive functioning
inability to concentration, lack of awareness of surroundings, incoherent speech, amnesia
Physical/Somatic Symptoms
HA, nausea/vomiting, dizziness, sensitivity to light & noise
Seep disturbances
Pathophysiology of TBI
Primary injury
initial impact that causes the displacement and injury of the brain
Secondary injury
the changes that occur after the initial incident
cascade of cellular and biochemical events including release of excitatory neurotransmitters
Complications of a TBI
Post-concussive symptoms
Persistent symptoms seen in about 10-20% of patients with a concussion
>2weeks in adults
>4weeks in children
Typically treated with physical rehab, as well as psychotherapy & physiotherapy
Second Impact Syndrome
Rare phenomena
Seen when patient undergoes second blow when the initial injury has not had enough time to recover
Characterized by rapid intracranial swelling due to malignant cerebral edema
Chronic Traumatic Encephalopathy (CTE)
Slow, progressive neurodegeneration due to repeated head trauma
expect memory disturbances, personality changes, speech & gait issues
Involves Tau protein deposition
Evaluation of Mild TBI’s in the ED
HPI
Ask specifically about mechanism, timing, severity of symptoms
PMH
Ask about prior TBI’s, co-morbid mood disorder/migraines/sleep disturbances
Exam
SCAT5 can be used as an adjunct to the physical exam
Imaging
Use clinical decision rules such as Canadian Head CT rules, NEXUS criteria, etc.
Disposition
Indications for admission
GCS<15, focal neurological deficits, seizures
Intractable vomiting
Significant Abnormal CT results
Discharge criteria
Normal GCS, exam
Caregiver at home
Certain abnormal CT
Isolated & non-depressed calvarial skull fractures
<1cm diameter of solitary cerebral contusions
<1cm width of epidural or SDH
Stable, trace SAH
If planning to discharge, appropriate counseling in the ED is especially important
Discuss expected symptoms
emotional/cognitive/physical symptoms, as well as sleep disturbances
Discuss expected timeline for recovery
usually 2-4 weeks to return to baseline
Arrange outpatient follow-up
Typically want follow-up in 2 weeks
This is due to the high prevalence of incomplete recovery months down the road
May need PM&R, PT, OT, etc. in the future
Counsel for return to activity
Prescribed rest for the first 24-48h
Still try to do ADL’s at home that do not exacerbate symptoms
Do NOT need to sit still in a dark lit room
Then, gradual return to physical activity/work
Stepwise approach on a daily basis
Aerobic exercise as tolerated and limited by symptoms
Do not return to sports until
Asymptomatic
Plus, cleared by a provider
AIR CARE GRAND ROUNDS WITH DRs. hinckley, goff, & winslow
TOWAR Study
Acronym for Type O Whole blood & Assessment of Age during prehospital Resuscitation)
Purpose of study is to assess if whole blood is the best resuscitative agent for trauma patients in hemorrhagic shock
Primary end-point
30d mortality
Secondary end-points
Lower early mortality
Lower blood transfusion requirements
Lower incidence of coagulopathy
Improved hemostasis
Improved platelet function
This is a multi-center trial
Locally includes UCMC and University of Louisville
Yet, enrollment in TOWAR study should NOT dictate where the patient is being transported
Of note, CCHMC is not participating in TOWAR study
Please do not administer O+ whole blood to >18yo trauma patients going to CCHMC
Randomized by Air Care base & on a monthly basis
Need to check calendar at start of your shift to know what components are inside blood cooler at your specific base that day
If TOWAR month: expect 2u O+ whole blood, 1u pRBC’s, 2u FFP in cooler
If not a TOWAR month: expect 2u pRBC’s, 2u FFP in cooler
This study qualifies for exception from informed consent (aka a EFIC trial)
May encounter patients in community with armband that exempts them from TOWAR study
Inclusion Criteria
SBP ≤90mmHg and/or HR≥108bpm
These vitals do NOT need to be present at the same time
These vitals can occur at ANYTIME, including prior to AC’s arrival
Or, SBP ≤70mmHg regardless of HR
Regardless of actual time of the injury
Exclusion Criteria
‘NO TOWAR’ bracelet
Objection for TOWAR study by patient or family members at the scene
Age >90yo or <18yo
Isolated fall from standing
Isolated drowning or hanging
Isolated burns WITHOUT evidence of traumatic injury
Known prisoner and/or pregnancy
Traumatic arrest with >5m of CPR without ROSC prior to enrollment
Penetrating brain injury or brain matter exposure
Unable to obtain IV or IO access
Women of childbearing age
If meet TOWAR study criteria, can administer whole blood
If does not meet TOWAR study criteria, can still consider whole blood administration if needed
May start with components
Then, whole blood if needed
If blood cooler is opened, please enroll patient in study BEFORE leaving UCMC
Call 513-558-6223
Complete QR code survey (found on badge buddy, inside cooler lid, by elevators near helipad)
Pediatric Scene Call: Status Epilepticus
New-onset pediatric seizure
Consider CNS involvement including meningitis/encephalitis triggering new onset seizures
Core competencies in all Air Care missions:
Obtain a history from whomever is at bedside (family, EMS, hospital staff)
Followed by a primary survey (organized by ABCD for medical and MARCH3 for trauma) - insist upon and respect the information from EMS while moving forward in an intentional and focused fashion!
Point of care glucose for any patient with altered mental status
Establish the weight of the patient early on, particularly in pediatrics, and have a reference tool ready
Reference tools include Air Care RSI book, Pedi Stat app, Broslow tape
If possible, try to determine age or estimated weight on the way to the call and prepare reference as well as equipment if needed
turn on vent to allow pre-checks, switch out circuits if less than 3 kg, pull specialty cells from critical care bag
Air Care has the tools to begin treating sepsis in the undifferentiated patient
Initiate volume resuscitation
Remember that there is 1 liter of LR in the MN tube kit
Broad-spectrum antibiotics (cefepime)
Status epilepticus
Definitions
Seizure refractory to medications or patient does not return to baseline between seizures
Seizures lasting greater than 5 minutes are at increased risk of becoming refractory to interventions and seizures lasting greater than 30 min contribute to cytotoxicity and neuron death - escalate care to obtain control by 30 min!
Start treatment of seizure with benzodiazepines
midazolam IM or lorazepam IV/IO
May repeat benzodiazepine and add a second AED
Keppra on Air Care
Load the patient to the extent possible (2g max on aircraft)
If patient remains refractory complete RSI to support airway and initial additional agents with anti-epileptic properties
Induction agents including ketamine, propofol, midazolam
Transport to a center with comprehensive neuro capabilities such as EEG
Pediatric RSI
Use a reference aid as noted above and seek a DASH1a airway
Baseline measures to support improvement in DASH1a success:
Resuscitate before you intubate (blood products, IVF if indicated)
Utilize apneic oxygenation
Utilize the RSI checklist
Video laryngoscopy with McGrath VL device
Bougie first intubation when using standard geometry blade
New measures contributing to improvement:
Air Care monitors during RSI
Seek to achieve at least an SpO2 of 97% before first attempt
If SBP<100 mmHg, give push dose pressors (Epi, Neo)
BVM through induction
Safe pressures on manometer (<20 cm H2O)
Open airway via jaw thrust by assistant
If using rocuronium as paralytic, dose at 1.5 mg/kg of IBW
Seek to match a patient's minute ventilation with TV and RR after intubation
Intentionally match patient's intrinsic RR noted prior to intubation
Note that healthy lungs can handle 8 mL/kg, based on IBW, if that is useful for compensation
Secure your ETT
Thomas Tube Holder is a new ETT holder on Air Care for ETT down to size 6.5
otherwise use the standard twill tape
Air Care Documentation in emsCHARTS
During the second half of the academic year, R1’s should complete charts in emsCHARTS
Especially when they are the provider in the doc’s seat
EMS charts will cross over into Epic in real-time
Importance of completing charts in a timely matter
Ideally, charts should be completed within 24 hours of the flight
Documentation tips/tricks
Page 2
Impression: is most important to complete (red flag, aka hard stop, if not completed)
CC: put patient’s complaints, as well as their actual diagnosis (ex: AMS, SDH)
Patient belongings: discuss with flight nurse who is completing this section
Air Care HPI
Discuss everything that happened PRIOR to air care’s arrival
This includes test results, such as troponin levels & glucose
As well as interventions, such as heparin ggt initiation & cervical collar application
Physical exam
In general, free-text is better than click boxes
Should be as thorough as your documented physical exam in the ED
Do not forget the neuro exam (page 3)
LOC, pupil findings, sensory, motor exam
GCS is a hard stop (note that you are unable to write ‘T’ for GCS score)
Can write your full neuro exam in the comments section on page 3 as well
Respiratory exam (page 4)
Write full respiratory exam under breath sounds section
Add vent settings from referral center in ventilator tab
Cardiac exam (page 4)
Write exam under cardio exam comments
Overall physical exam (page 5)
General extremities tab- good place to write no trauma to extremities
If a full neuro, resp, cardiovascular exam where appropriately documented on page 3 & 4, there is no need to repeat things on page 5
Activity log (page 8)
Where documentation for performed procedures is inserted
Need to click add “action” to add a procedure
Use procedure templates found on emsCHARTS
human resources tab-> document warehouse -> references:documentation
Copy and paste these templates into the action tab on page 8, then fill out appropriately
Narrative
Includes information from when Air Care arrives, until patient arrives to receiving facility & care is rendered
May sometimes include information before you meet the patient, such as delays experienced
Need indication for flight at the top of the note
For example, patient with cardiogenic shock and needs transport to CVICU with cardiac surgery capabilities
Narrative includes the medical decision making process
For trauma patients, use MARCH format for documentation
Massive hemorrhage including sources and interventions
Airway including ETT, RSI meds
Respiratory
Circulation including form of IV access
H has three components (head injury, hypothermia, hypoglycemia)
For medical patient, use typical ABCD format for documentation
Remainder of narrative involves what you did and explaining the medical decision-making process behind your actions
As well as what you didn’t do and why
Interpretation of labs, exam, etc.
Include PR callback information at the bottom
Sign chart and push it
Review yellow flags, yet do not need to necessarily fix to push the chart
Meanwhile, red flags are a hard stop for pushing the chart
Charts need to be pushed within 24 hours of the flight (72h at the latest)
All charts undergo a formal QA process