Grand Rounds Recap 5.25.22


Doom From Down Under WITH VISITING PROFESSOR DR. JENNY BECK-ESMAY

Case 1: An Unusual Presentation of Ectopic Pregnancy

  • The Case: A teenage female presents with sudden onset LLE pain. 

    • Described as aching in the calf onset while walking to school, extends proximally up posterior leg to hip, walking with a limp. 

    • Physical exam notable for tachycardia but no other abnormal findings, specifically normal MSK exam. Appears uncomfortable, LMP 2 months ago, hx of irregular menses, +vaginal bleeding today, mild abdominal pain although states is chronic. 

    • PMHx GERD, ovarian cyst. Not on OCPs. 

    • Workup: Positive pregnancy test, hemoglobin to 9 from 12, TVUS showed ruptured ectopic and moderate free fluid in pelvis, no abdominal tenderness, negative FAST exam

  • Ectopic pregnancy:

    • Occurs in 1.5-2% of all pregnancies

    • Up to 18% of patients who present to ED in first trimester w/ vaginal bleeding are found to have ectopics

    • Leading cause of pregnancy-related maternal death in first trimester and accounts for 3-6% of all pregnancy-related maternal deaths

    • Don’t be reassured by normal/low-normal heart rates as stimulation of vagal response by hemoperitoneum can lead to bradycardia when otherwise would expect tachycardia from hemorrhagic shock

  • Obstetric/pelvic etiology of sciatica is common – be sure to consider the pelvic mass in new onset of symptoms if remainder of clinical picture is unclear

  • Management of ectopic pregnancy

    • Medical

      • Methotrexate 

        • Contraindications: fetal cardiac activity, serum hCG >5000-10000 depending on local practice, signs of impending tubal rupture or concern for large size of ectopic mass, heterotopic with viable IUP, breastfeeding, immunodeficiency, PUD, active pulmonary disease

        • Counseling for methotrexate: must be trended to bHCG of zero, ectopics can rupture at any time in the resolution phase of ectopic

        • Up to ⅔ women can have separation pain ~1wk after MTX treatment →no treatment needed, is thought to be due to tubal distension

      • Expectant management - measurement of serum hCG levels every 2-3d until undetectable, assuming levels are decreasing as expected and pt remains asymptomatic.

        • Can take up to 10weeks for hCG to be completely negative

    • Surgical

Case 2: Toxic Shock Syndrome

  • The Case: A healthy teenage female presents with 2-3 days fever, vomiting, malaise, diarrhea, maculopapular rash. LMP started 5 days ago but has now stopped, never been sexually active, denies vaginal bleeding or discharge. 

    • Vitals grossly abnormal on presentation with hypotension, febrile, tachycardia. 

    • Labs show WBC 24, plt 92, creatinine 6, lactate 3.8

    • Physical exam notable for diffuse rash and lower abdominal pain. Pelvic exam performed with purulent vaginal discharge and a tampon in place (pt reports she thought she had taken out several days ago)

    • Hospital course notable for ICU admission with pressor requirements but ultimately grew staph aureus from vaginal swab. Patient ultimately made complete recovery. 

  • Toxic Shock Syndrome (TSS)

    • Typical causative organisms is staph aureus or strep species

    • Clinical constellation includes fever, septic shock, desquamation of palms and soles, diarrhea, diffuse erythematous rash

      • Often has prodromal period with more flu-like symptoms prior to significant clinical decline and development of shock

    • Significant rise in incidence after patent filing of tampax in 1936, high as 10/10000, now dropped to ~1-3/10000 by 1980s and remained stable.

      • Higher association of TSS with super absorbent tampons or in patients who used tampons continuously for non menstrual bleeding → decreased incidence coincides with removal of highest absorbency tampons from the commercial market

    • Treatment includes early antibiotics and source control aka removal of infectious nidus if present

      • empiric therapy = vancomycin + clindamycin + piperacillin-tazobactam OR cefepime OR meropenem

      • Can require surgical debridement in advanced cases or if abscess present

      • IVIG can be considered in cases refractory to vasopressors

  • In cases of undifferentiated sepsis, do not forget to consider GU/Gyn source

Case 3: Pelvic Inflammatory Disease and Tuboovarian Abscesses 

  • The Case: A middle aged female with PMHx of obesity initially presented to OB/Gyn with urinary frequency and RLQ pain. Diagnosed with UTI and started on nitrofurantoin. Presented to the ED 6 days later with reports on no clinical improvement despite taking the antibiotics and now is having worsening pain which is radiating to her back. In the ED, was febrile, tachycardic. UA repeated which was normal but providers think may be secondary to her already being on antibiotic therapy and diagnose her with pyelonephritis. No blood work obtained. She is discharged on sulfamethoxazole-trimethoprim. 3 days after her ED visit, has sudden onset of shortness of breath at home with syncope. EMS brings her to the ED where she suffers a cardiac arrest and expires.

    • Autopsy reveals cause of death was sepsis from pelvic inflammatory disease with right tubo ovarian abscess and peritonitis 

    • Became a medical malpractice case due to lack of performing (or documentation of offering to patient) labs, pelvic exam with a $1.2 million dollar settlement. 

      • Consider anchoring bias,

  • PID/TOAs

    • 1 million cases annually in the US

    • Complications after PID: 

      • PEACH Study - evaluated risk of reproductive sequelae in 800 American women who were treated for clinically diagnosed mild-to-moderate PID within 3 years→ 18% infertility, 0.6% ectopic pregnancy, 29% chronic pelvic pain, 15% recurrent PID

        • Delayed treatment leads to worse complications

    • Diagnosis of TOA → CT better than US in terms of both sensitivity and specificity

      • Also helps with drainage/surgical planning

      • Use as first line imaging in non-pregnant patients

    • Treatment and disposition:

      • Admit patients who are pregnant, are unable to reliably complete therapy as an outpatient (access to medications, ability to take appropriately, etc), those who present with severe disease manifestations including sepsis or TOA 

      • Outpatient treatment = 500mg ceftriaxone IM once + doxycycline 100mg BID x10d + metronidazole 500mg BID x14d

  • History of the pelvic exam and pelvic speculum

    • Vaginal visualization devices have been found as far back as in the ruins of Pompeii

    • Given the sensitive nature of this exam and disturbing attitudes throughout history regarding the importance of consent for the performing of it, some states are increasingly passing stricter laws about the ability to perform these exams. 

      • Bottom line, get consent if not critical to the life-saving management of an unstable patient (like the patient in TSS in Case 2)

    • 2011 WEJM study evaluated predictability of pelvic exam findings in ~180 women → pelvic exam findings are predictable or don’t change management 94% of the time.

      • That 6% miss rate is still not acceptable per EM standards of care → just do the pelvic exam if you’re even remotely thinking about it (or at least discuss with patient and document)

Case 4: Ovarian Torsion

  • The Case: A young female with PMHx of PCOS presents with LLQ pain starting today without vaginal bleeding or cramping. Physical exam with LLQ pain on palpation and L adnexal tenderness without masses. Pelvic ultrasound shows a left adnexal cyst with no sonographic evidence of torsion. Patient still in exquisite pain, poorly managed with opiate analgesia. After being consulted, gynecology takes her to the OR and finds a torsed left ovary. 

  • Ovarian Torsion

    • Presentation

      • Most common presenting symptom is pain

        • 90% report pelvic pain but can also have back or flank pain

      • Vast majority describe pain as sudden onset

      • Wide variety in description of quality of pain

      • Up to 20% will have low grade fever

    • Diagnosis 

      • Must maintain high clinical suspicion (beware the bad exam!)

      • Pelvic exams are overall largely unreliable for detection of pelvic masses or adnexal abnormalities (even by gyns on exams performed under anesthesia)

        • ED interrelated reliability is especially poor for detection of adnexal tenderness or pelvic masses

      • US has high specificity but poor sensitivity

        • Most sensitive marker of torsion is unilateral ovarian enlargement (~80% sensitivity)

        • String-of-pearls sign is very specific

        • Dopplers aren’t great (60% of torsion cases have normal blood flow) due to the dual arterial blood supply of the adnexa

          • Also are less adept at detecting venous abnormality which can precede arterial occlusion and also is detrimental to ovarian viability by itself


Effective Lifelong Learning WITH VISITING PROFESSOR DR. JENNY BECK-ESMAY

There is simply too much information available in modern medicine for physicians to be expected to have all appropriate knowledge at all times

  • Amplified by the development of increasingly more medical subspecialties

  • Limited data that participating in CME improves job satisfaction

  • Barriers:

    • Lack of motivation

    • Inadequate time for dedicated CME

    • Limited resources, both in terms of educational content and financial

    • Lack of awareness → “you don’t know what you don’t know”

    • Ambivalence or reluctance to change

    • Group think → don’t want to be the odd man out if no

    • Majority of education currently is in a passive learning format and is not conducive to building skills necessary for effective lifelong learning → people may just not know where to start or how to do this after graduation from a structured learning/training environment

  • Is CME effective?

    • 2015 Study in the Journal of Continuing Education in Health Professions showed that CME has a high positive impact on physician performance. There was a positive trend in patient outcomes but not significant.

    • CME was more effective if it was interactive, used a variety of methods, incorporated longer sessions and spaced repetition and if it was on topics that were identified as important by the physicians themselves rather than mandated from outside body

  • Meaningful features in lifelong learning in physicians

    • Recognition of need by the individual themselves

    • Self initiation

    • Personal motivation

  • How to Learn Better

    • Take Charge - be the grown up you know you are

    • Be organized

    • Learn at work

      • Just in time learning, CME (best in groups)

      • Seek evidence of your own efficacy (follow up patients, get data, etc)

    • Solicit Feedback

    • Find ways to use evidence-based medicine at point of care/in real time

  • Information Management

    • Focuses on usefulness of information to patient care

      • Usefulness = (Relevance)(Validity) / Work

        • Relevance - direct applicability to the patient care

        • Validity - technical rigor in terms of EMB

        • Work - time, money, effort, etc needed to get your answer/information

    • Foraging tools - alert people to new, relevant, valid information. This is how you learn information exists

    • Hunting tools - allow you to find information again, quickly, exactly when you need it

  • Recommended Resources

    • News aggregator

      • Feedly, flipboard, nuzzle, etc

      • Acts as a “foraging tool” manager

    • “Read by QXMD” app - articles/journal subscription

      • Also allows you to follow collections curated by other people

    • Twitter

      • @foamstarter is a good place to start

      • Allows for engagement and discussion, rather than just passive reading

      • Be careful, the role of influencers and viral conversations can sway EMB and data-supported practices drastically

    • Googlefoam.com

      • Run by the people who run LITFL

      • Is a “hunting tool”

      • Preferentially searches all FOAM sites and medical literature rather than general google

        • Eliminates the WebMD, etc.

  • Critical thinking re: secondary resources (UpToDate, etc)

    • Questions you can ask/consider for every FOAM resources

      • What if something is published with incorrect information?

      • What if the early studies don’t match more recent data?

      • What if something fails replication or validation?

      • What if I misinterpret as I’m reading?

      • Has the standard of care changed since this was published?

    • Teresa Chan FOAMEd Appraisal Questions

      • Is this at the right level for me?

      • Is it just an opinion?

      • Has it been peer reviewed?

      • Is this author credible? What are their credentials?

      • Are they using their own words?

      • Are the authors or aggregators transparent?

      • Any conflicts of interest?

    • Ranking and Critical Evaluation

      • AIR (approved instructional resources) Score by ALIEM - developed for EM FOAMEd specifically

      • METRIQ score (medical education translational resources impact and quality score)

      • Social media index - impact assessment of FOAM sites

  • Building a Foundation:

    • Canadiem podcast - each episode goes through a chapter of Rosen’s 

    • Don’t diss the textbook


Morbidity and Mortality Conference WITH DR. COLLEEN LAURENCE

Aortic Dissection and Pericardial Tamponade

  • Aortic dissections are classified into Stanford A or B, or less commonly Debakey Types I-III

    • ⅔ of dissections are Stanford Type A

  • Pericardial effusions in Stanford Type A dissections

    • Develop either by transudative fluid movement across the thin-walled dissection flap tissue (more common) or through direct rupture of adventia by dissection flap

    • ⅓ of patients w/ have hemodynamically insignificant effusions 

    • 8-31% develop tamponade

      • Tamponade is the most common cause of prehospital death in patients 

      • Presence of tamponade physiology doubles perioperative and in-hospital mortality

  • Should we drain these effusions?

    • Used to be more controversial -> rapid drainage previously thought to lead to increase in BP which subsequently worsened dissection and created a vicious cycle of clinical decline

      • Based on very small retrospective study from 1994 where average volume drained by pericardiocentesis was 100-300mL and SBP increased by 40-80mmHg

    • More recent data suggests that controlled drainage shown to be relatively more successful in terms of sustained survival

    • 2010 AHA and 2015 ESC guidelines changed to recommend controlled drainage to achieve SBP not greater than 90mmHg and to not exceed 50mL drainage at one time

  • Procedural Quick Hit: Pericardiocentesis

    • Can be done blind although better to do US-guided if available, even in an arrest situation

      • Complication rate much lower with US-guided (0.5-3.7%) compared to blind/ECG-guided (15-20%)

    • Three possible locations for needle insertion:

      • Subxiphoid (1-2 finger breadths to left of xiphoid, inserting needle at 45º-angle towards left shoulder)

        • Site of choice for ATLS

        • Most common blind-approach

      • Parasternal (4th intercostal space along left sternal border, needle perpendicular to skin)

        • Site of choice for ACLS

      • Apical (must be US-guided, needle inserted in plane with phased array probe from location with best AP4 view)

    • Complications of a pericardiocentesis include:

      • Puncture of right ventricle, stomach, or liver

      • Pneumothorax

      • Infection

      • Life-threatening Hemorrhage

    • Considerations for site choice

      • Mean skin to pericardial fluid distance is largest in subxiphoid (5.6cm) vs parasternal and apical which are ~2.5cm)

      • Highest predicted complication rate subxiphoid > apical > parasternal

        • Matches actual data

      • Patient factors including habitus or active compressions

    • Tip and Tricks

      • Have someone else hold the probe for you

      • Confirm location w/ injection of 1-2mL agitated saline

      • Decrease depth to improve resolution of needle (just need to see fluid and most anterior cardiac tissue)

      • Consider placement of an indwelling pigtail or CVL for maintaining access and allowing for ongoing drainage if needed

Posterior Stroke

  • Posterior circulation (PC) strokes account for ~20% of all strokes with 2x the rate of misdiagnosis as anterior circulation

  • Variable presentation including but not limited to: dizziness, vertigo, dysarthria, atypical motor deficit distribution, nausea and vomiting, altered mental status

  • Treatment

    • tPA has long been considered only option as PC strokes were not included in many seminal thrombectomy efficacy trials (eg. HERMES) 

    • Recent metaanalysis of 12000+ patients over 18 studies evaluating mechanical thrombectomy (2022) in these patients found

      • Comparable rates of successful mechanical thrombectomy (TICI>2) in posterior strokes compared to anterior

      • Patients with PC LVOs s/p thrombectomy had

        • decreased odds of functional 90d outcome as defined as modified Rankin Score 0-2 (OR1.26, CI 1-1.59)

        • increased odds of 90d mortality (OR 0.58 favoring anterior circulation LVOs)

        • Theorized to be in part due to delay in diagnosis for PC strokes

  • Consenting for tPA

    • ACEP guidelines recommend shared decision making and obtaining consent prior to tPA administration

      • No standardized approach is provided

      • tPA is FDA approved for 0-3 hour window and technically does not require consent in that time frame

    • Surveys of national practice patterns show ED docs are overall not consistent with their shared decision making and obtaining consent for tPA

      • Being an emergency physician (as compared to neurology, for example) and practicing in a non-academic institution associated with increased tendency to always obtain consent for tPA

      • Increased consent obtained in 3-4.5hr window compared 0-3h

    • Statistics you can use for your own tPA shared decision making script:

      • One of every three patients treated showed some functional improvement after tPA administration

        • Odds of little to no long term disability increase from ~38% → 50% after tPA

      • Only 1/100 will have severely disabling or fatal outcome from ICH after tPA administration

      • Find your favorite infographic to use with patients for improved communication

Infective Endocarditis

  • Hard to diagnose

    • Nonspecific signs and symptoms, most often similar to flu-like illness

      • Malaise (80%), fever (90%), headache, weakness, arthralgias

    • Most “classic” physical exam findings are rare, poorly sensitive and often more subacute

      • Murmurs are present in ~85% of cases!

    • Right-sided endocarditis usually presents with more acute illness, shock

    • Left-sided endocarditis often more indolent, flu-like and nonspecific

  • High risk patients:

    • Known valvular disease, prior endocarditis (HR 65), or structural heart abnormalities (congenital or acquired)

    • Nosocomial-Associated

      • Prosthetic valve (HR 19)

      • Endovascular hardware (pacemaker, PICC, etc)

    • IDVU/PWID

      • High risk for multiple episodes with up to ⅓ having at least 2

    • Hemodialysis patients

    • Immunosuppression (including diabetes)

  • Diagnosis

    • Modified Duke Criteria → not really in the scope of practice for ED

    • Blood Cultures

      • Get 3 or 4, with at least 1 hour between first and last

        • 90% speciate with ≥2 cultures

        • 98% speciate with ≥3 cultures

      • Are negative in 5-20% of cases even with appropriate technique

      • More blood is more better (increased sample volume improves sensitivity) → aim for 20cc/bottle

      • Collect from straight stick or new IV placement

    • TTE vs TEE

      • Even though we are not credentialed to evaluate valves on ED bedside echo, can place a comment if abnormality noted on scan

        • Cannot be directly used for diagnostic or management purposes, more to influence next steps (call cardiology, get comprehensive study, etc.)

      • Comprehensive TTE carries pooled sensitivity of 71%, pooled specificity of 80%, pooled +LR 3.5, -LR 3.7.

        • Has better sensitivity for right sided endocarditis

        • Prosthetic valves difficult to evaluate with TTE

        • If vegetations seen, increased size improves sensitivity

    • Other labs including leukocytosis, inflammatory markers are poorly sensitive

Hemoptysis

  • Hemoptysis is blood expectorated from tracheobronchial tree or lung parenchyma vs. pseudohemoptysis is blood expectorated from nasopharynx, larynx, or GI tract

  • Classically, massive is defined as 100mL to 1L in a 24hr period

    • Very hard to quantify, both by providers and patients

    • More relevant to determine how the patient is handling the bleeding vs. sheer volume alone

      • Taking into account gas exchange, hemodynamics

  • Most common cause is infection (TB #1 worldwide)

    • Can be caused by end-stage primary pulmonary pathologies, malignancy, trauma, iatrogenic injury, fistula development

  • 90% of massive hemoptysis bleeding originates from bronchial arterial system which is under systemic pressure

    • 5% each from pulmonary arteries and “other”

  • Diagnostics

    • Labs, CXR (can identify source of bleeding in most cases), CTA +/- bronchoscopy

      • CT has very high sensitivities for identifying both site and cause of bleeding and is helpful for IR/interventional planning but requires stabilization

      • CT often more helpful in identification of bleeding source than bronchoscopy due to the difficulty with direct visualization in the setting of large volume active bleeding

  • Airway management

    • Warning signs = ineffective cough, anticipated course, worsening respiratory 

    • Anticipate all the difficulty - HOB up, biggest ETT you can (at least 7.5), have a DL option with surgical airway setup, SUCTION, address coagulopathy in advance

    • Do not use double lumen tubes in ED - often misplaced in ED and do not standard accommodate bronch wands

  • Bleeding Management

    • Reverse pts on anticoagulant therapy or who are coagulopathic for other reasons

    • Product resuscitation but consider permissive hypotension

    • Nebulized TXA has some evidence in non-massive hemoptysis but unlikely to reach site of bleeding in event of massive hemoptysis so less effective

    • Almost no data on systemic TXA

  • Disposition and prognosis

    • Very high mortality rate and high risk of recurrence if severe enough to require embolization

Hickam’s Dictum and Other Quick Hit Case Lessons

  • Gout predisposes patients to VTE, most commonly in the 1 year preceding initial diagnosis

    • most commonly manifests as PE 

  • Postpericardiotomy pain syndrome is a febrile illness secondary to autoimmune reaction after incision to pericardium

    • Typically occurs as a single episode 3-6 months after inciting event although can occur at any time post-operatively

    • 10-40% incidence, can lead to tamponade or constrictive pericarditis

  • Differential diagnosis for persistent (>48h) or intractable (>1mo) hiccups includes stroke, intracranial lesion, encephalitis, acute myocardial infarction, pericarditis, pneumonia, GERD, bowel obstruction, medication adverse effect, hyponatremia or post-procedural complication

    • GERD most common cause

  • Occam’s razor (“entities should not be multiplied beyond necessity”) is useful but not infallible

    • The simplest explanation is often the correct one

  • Hickam’s Dictum (patients can have as many diseases as they darn well please) comes into play often in patients with significant comorbidities

    • Do not force a round peg into a square hole–if things aren’t adding up, check your assumptions, go back to the patient and get more information, consider more diagnostics, ask for second opinions.