Grand Rounds Recap 6.22.22


Morbidity and Mortality WITH Dr. Frederick

Case 1: STREMI (new word) - Simultaneous STEMI and Acute Ischemic Stroke

  • Discuss concerning EKGs with the on call interventionist, even when EKG does not meet STEMI criteria. They may still offer LHC and may uncover intervenable disease.

  • Dynamic EKG changes are common in ACS presentations, obtain repeat EKGs

  • Simultaneous acute ischemic stroke (AIS) and acute MI is rare, 0.9 per 100,000

  • Shared risk factors, systemic inflammatory response, possible embolic sources may cause co-presentations

  • Left insular stroke is associated with adverse cardiac outcomes; RR 1.75

Management:

  • ACS

    • Thrombolysis indicated if no PCI available < 120 minutes presenting within 12 hours

    • Mechanical reperfusion is first line

    • Heparin recommended with poor evidence (1C for STEMI, 1B for UA/NSTEMI)

    • ASA and antiplatelets indicated within 24 hours

  • AIS

    • Thrombolysis indicated if < 4.5 hours

    • Mechanical reperfusion recommended in LVO

    • Heparin generally contraindicated

    • ASA and antiplatelets are indicated if no tPA administered

  • Combined presentation

    • Thrombolysis should be offered if indicated for stroke treatment

    • Mechanical reperfusion warranted for both AIS/ACS

    • Heparin risk may outweigh benefit depending on stroke characteristics and neurology recommendations

    • ASA and antiplatelets are indicated if not administering tPA

  • For combined presentations, neurocritical care can be helpful to coordinate advanced therapies

 Case 2: Autoimmune Encephalitis

  • NMDA-R Encephalitis: Autoimmune disease in which autoantibodies are produced against synaptic NMDA receptors

  • Incidence is 1.5 cases per 1 million

  • Presents with prodrome fever, fatigue, headache (5-14d), followed by psychosis, attention difficulties, hallucinations, language difficulties, followed by seizures, catatonia and autonomic instability

    • Women present more with psychosis and hallucinations

    • Men present more with seizures, often focal

  • Workup

    • MRI

    • CSF

      • Pleocytosis​

      • Increased protein​

      • Oligoclonal bands​

      • NMDAR autoantibodies

    • EEG abnormal in 90-100% of cases

    • Investigate for neoplasm; pelvic ultrasound often helpful

  • Treatment

    • IV steroids, IVIG, plasmapheresis

    • Those that do not respond may need targeted B cell-therapy with rituximab, cyclophosphamide, or intrathecal methotrexate

  • Prognosis

    • 20% have significant deficits or progress to death

    • 75-80% will recover

      • 53% of patients show improvement within 1 month of starting immunotherapy and tumor removal

      • Typical hospital stay is 2-4 months

Case 3: Cardiac Arrest in the ED

  • ESI level dependent on vitals and resource utilization

  • Patients are under triaged ~17% of the time

    • Age > 70, bradycardia or tachycardia, tachypnea, syncope, chest pain, hypoxemia, arrival between 0100-1300 all have been shown to predispose to under triaging ESI levels

  • Clarify roles of resuscitation, especially when patients start in other care areas and are moved to the SRU

  • Be mindful of subconscious bias toward ‘difficult’ patients

    • Shown to have poorer pain control, fewer offers for admission, less time in the room communicating plans

Case 4: Acetaminophen Toxicity

  • Factors affecting toxicity

    • Acute alcohol intoxication

      • Decrease conversion to NAPQI, protective against toxicity

    • Chronic alcohol use

      • Decreases glutathione stores, increased risk of toxicity

    • Tobacco use increases CYP metabolism, increases risk of toxicity

    • Age < 5 is protective (underdeveloped CYP metabolism), age > 40 increases risk of toxicity

    • Fasting decreases carbohydrate reserves, decreases glucuronidation, increased risk for hepatotoxicity

  • Workup

    • Obtain APAP level 4 hours after (acute) ingestion, or on arrival if later

      • If ingestion time unknown, draw second level 4 hours after first

  • Treatment

    • NAC should be started within 8 hours, IV treatment is equivalent to PO

    • Indications for treatment

      • Supratherapeutic APAP (>150 ug/mL) at 4 hours

      • If unknown time of ingestion

        • Draw a level now and in 4 hours​

        • If initial level is undetectable, treatment with NAC is decided based on laboratory or clinical signs of hepatotoxicity​

        • If >8hrs from ingestion, NAC should be given empirically while awaiting APAP level. ​

      • For repeated ingestions:

        • Ingestion of >7.5g in 24 hours, or >4g in 24 hours with factors that increase risk for hepatotoxicity​

        • Supratherapeutic APAP Level (>20mcg/mL)​

        • Elevated ALT/AST >50 on presentation​

        • Elevated acetaminophen-aminotransferase multiplication product​

          • APAP x ALT > 10,000 = Treatment​

          • APAP x ALT < 1,500 = Toxicity unlikely to develop​

  • Anaphylactoid reaction to NAC is possible in 8%, if this occurs then slow infusion rate. This is often not a true IgE mediated allergic response. 

  • Typical clinical course:

    • 0-24 hours = Symptomatic presentation​

    • 24-72 hours = Initial liver injury on labs​

    • 72-120 hours = Peak liver failure + mortality​

    • 1 week + = Recovery

  • See the 2021 Annals of B Pod article on this topic

Case 5: Pyoderma Gangrenosum

  • Pyoderma gangrenosum = neutrophilic inflammation of the skin often associated with underlying systemic illness

    • 41% IBD

    • 21% inflammatory arthritis

    • 7% solid organ malignancy

    • 6% hematologic malignancy

  • Treatment is local wound care and treat underlying disorder

    • Immunosuppressive therapy if no response with treatment of the underlying condition

  • Approach to rashes:        

    • Primary morphology:

      • Macule, patch, papule, nodules, plaques, bullae, vesicle, pustule

    • Secondary morphology:

      • Erosion, ulceration, fissure, atrophy, excoriation

      • Crusting, lichenification, scaling

  • Modified lynch algorithm can help identify etiology of emergent rashes based on appearance

  • Be aware of varying appearances of rashes in patients with differing skin complexion

  • Dermatology for the non-dermatologist


Social Emergency Medicine WITH Dr. Jarrell

  • The ED is the social barometer of its community. It is the confluence of social determinants of health and their deconstruction into pathology.

  • Update on SEM projects within UCMC

    • SEM Fellow - Dr. Pulvino

    • Public Health Leadership Academy - Dr. Pulvino, Dr. Berger, Dr. Laurence

    • Early Intervention Program RAMD - Dr. Gressick

    • SEM Electives offered

      • Advanced SEM

      • Human trafficking (in progress)

      • Medical Spanish

      • Advocacy

    • Our residents are involved in multiple national projects within the Social EM Education Subcommittee

      • Joint committee between SAEM, ACEP, EMRA

      • EMRA representation

        • Dr. Kimmel - SEM Committee Chair Elect

        • Dr. Yates - Health Policy Committee Assistant Vice Chair

    • ESL Workgroup

      • Appropriate use of interpreters - faculty and residents

      • Updating discharge resources in multiple languages

    • TamingtheSRU and Annals of B Pod articles - Dr. Stark

  • Reflections on path to SEM:

    • Not everyone has the same exposure to careers in medicine

    • We must be conscious of not only the availability of a resource within a community, but the ability to access this resource for specific members of a community. 

    • Be mindful of ad hominem view of disease - focus on precipitants of disease in addition to the symptoms

      • Ex: Addressing underlying trauma that precipitates alcohol use disorder, leading to unstable housing

      • Ex: Diabetes may be uncontrolled because patients have no place to keep their insulin


Airway grand rounds WITH Dr. Carleton

  • Intubation is not a benign process:

    • Cardiac arrest 2-4%, desaturation rate 20-40%, hypotension rate 10-40%

  • Assess for physiologic difficulty

    • Hypoxia

      • Obesity, shunt physiology, oxygen consumption, anemia, low FVC

    • Hypotension

      • Positive pressure effects on the circulation, vasoactive drugs, differential RV, LV hemodynamics, hypovolemia

    • Risk of Apnea

      • Metabolic acidosis

  • Optimize patient prior to attempt

    • Hypotensive?  IVFs, Blood, Pressors

    • Hypoxic?  Upright, Maximize Pre-ox/Ap-ox

    • Acidotic?  Pseudo-NIPPV, Awake technique

    • Preventing Desaturation = utilize NIPPV when possible

  • Optimize reservoir by maximizing FRC

    • De-nitrogenate/oxygenate volume in the reservoir

    • Make sure gas in reservoir is available for circulation

      • Utilize Ap-Ox

  • Strategies for high to refractory hypoxemia

    • Maintain spontaneous breathing

    • HFNO Preoxygenation

    • Upright position

    • iNO, epoprostenol (iNO faster to obtain in our ED)

    • Gentle transition to PPV

  • Strategies to mitigate hemodynamic instability:

    • Anticipate and assess hypovolemia/volume responsiveness and replete volume

    • Calculate the shock index

    • Prevent or reduce vasoplegia

    • Augment ventricular performance

    • Mitigate induction effects

    • Protect the RV

    • Ketamine may have high risk of immediate hemodynamic instability compared to etomidate; one study suggests etomidate has higher 7d mortality, but equal 28d mortality compared to ketamine

  • Considerations in acidosis

    • Recognize that apnea in RSI has physiologic consequences. 

      • For each increase in pCO2 by 10mmHg, pH drops by 0.08

    • Be mindful of minute ventilation after intubation, match or exceed pre-intubation MV; requires us to measure it before intubation

      • Assuming normal VCO2, minute ventilation required to maintain pCO2 = 60 mL/kg/min

    • Estimate or quantify VE pre-intubation using Bi-PAP for pre-oxygenation

    • Consider an awake technique to maintain their minute volume 

    • If using RSI, consider pseudo-NIPPV to attenuate worsening acidosis


R1 Clinical Knowledge: Asplenia WITH Dr. Negron

  • Anatomy

    • Receives 5% total cardiac output per minute​

    • White pulp = Lymphatic nodules where T cells envelop B cells​

    • Red pulp = Tight network of sinusoids and cells responsible for filtration and processing​

  • Function

    • Differentiations of WBC/adaptive immune response, production of antibodies

    • Activation of innate immune response

    • Storage of WBC and platelets

    • Filtering of blood 

  • Asplenia/Hyposplenia

    • Over 1 million people in the United States are asplenic

    • Cirrhosis, Celiac disease, Vasculitis, Spleen irradiation, Sickle Cell, Lupus, bone marrow transplant may produce functional asplenia

  • Complications

    • Risk of infection is 2-3 fold greater in asplenic patients compared to the general population

      • Risk is greatest in patients <5 y/o and >65 y/o​

      • For anatomic asplenia, risk greatest in first 2 years​

      • Overwhelming Post-splenectomy Infection (OPSI) is a potentially fatal condition with sudden decompensation from overwhelming bacterial infection, most often caused by S. pnemoniae​

        • OPSI annual incidence among asplenic patients is 0.5% however mortality is up to 70%

    • Pulmonary hypertension exists at 8-11% in this population

    • Higher risk for VTE

      • Platelet activation, loss of platelet storage, endothelial lining dysfunction and damage​

      • Risk of VTE after splenectomy of 10.7%, compared to 3.5% of patients undergoing other abdominal surgeries

      • Patients who underwent surgical splenectomy have RR of 2.2 for DVT, 2.2 for PE, and 4.5 for risk of death from PE

  • Approach to the asplenic patient

    • Complete H&P to assess for signs of infection

    • Broad spectrum antibiotics +/- Atypical coverage​

      • Adults: cefepime + vanc

      • Children: ceftriaxone + vanc

      • +/- azithromycin if concerned for pneumonia

    • May consider IVIG​

    • In vasopressor and fluid-resistant shock or concern for adrenal hemorrhage, treat for adrenal insufficiency with hydrocortisone

    • Higher risk for VTE

      • Platelet activation, loss of platelet storage, endothelial lining dysfunction and damage​

      • Risk of VTE after splenectomy of 10.7%, compared to 3.5% of patients undergoing other abdominal surgeries

      • Patients who underwent surgical splenectomy have RR of 2.2 for DVT, 2.2 for PE, and 4.5 for risk of death from PE5​


Taming the SRU: REBOA WITH Dr. Mullen

  • REBOA = Resuscitative endovascular balloon occlusion of the aorta

    • Zone 1 celiac trunk to left subclavian artery

    • Zone 2 celiac trunk to lower renal arteries

      • No indications for placement here

    • Zone 3 Iliac bifurcation to lower renal arteries

  • Indications

    • Hemorrhage due to trauma below the diaphragm

      • Suspected traumatic abdominal hemorrhage (Zone I REBOA)

      • Blunt pelvic injury or groin junctional hemorrhage (Zone III REBOA)

  • Placement considerations

    • Must know time of balloon tamponade = ischemia time

    • Confirm placement with X-ray

  • There is no high-grade evidence demonstrating that REBOA improves outcomes or survival compared with standard treatment of severe traumatic hemorrhage.

  • 2019 consensus statement from American College of Surgeons: “REBOA should only be placed by a surgeon or interventionalist responsible for definitive hemorrhage control or by a physician trained and qualified in REBOA in direct consultation with the physician who will provide definitive hemorrhage control. In all circumstances, these trained clinicians should be integrated within an appropriate system of care.”

    • Revised language that does not limit this procedure to surgeons, but should be done in conjunction with trauma team that can facilitate definite care